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In contrast to EAE where the primary stimulus is immune upregulation in the presence of extrinsic myelin antigens, the CAE model illustrates that MS-like pathology can also be generated by an upstream intrinsic myelin injury, releasing antigens which secondarily trigger white matter inflammation in an immune-predisposed host

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Payers cross-reference the diagnosis against their Local Coverage Determination (LCD) for epidural steroid injections