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GLP-1 Medications and Thyroid Safety: What the Research Shows GLP-1 receptor agonists including semaglutide work by slowing stomach emptying, increasing feelings of fullness, and improving blood sugar controlmechanisms that are independent of thyroid function

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In a MASH mouse model induced by a diet high in fat, fructose, and cholesterol for 34 weeks and treated with resmetirom for 8 weeks saw improvements in MASLD activity score with reduction in liver weight, hepatic steatosis, plasma alanine aminotransferase activity, liver and plasma cholesterol, and blood glucose

Taken together, these observations provide fresh insight into the role of the immune system and the IL-17/neutrophil axis in mediating ectopic calcification in rodent models of calciphylaxis