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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction

Adhering to Wegovy storage instructions ensures the remaining medication stays effective

The FDA approved an oral version (Rybelsus) which is a daily pill

Further randomized controlled trials and long-term observational studies are needed to validate its efficacy and safety profile

Patients experiencing persistent or severe skin problems should consult their GP for assessment and potential prescription treatments per NICE guidance