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The molecule loses biological activity through hydrolysis, oxidation, or aggregation while the solution still looks clear

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It is important to note that internalized nanoscale materials, including citrate-coated Ag NPs [453], polyvinylpyrrolidone-coated Ag NPs [453], and Si NPs [458], trigger eryptosis in a Ca 2+ -, ROS-, and calpain-mediated fashion (Fig