Long-term studies are needed to validate the potential cardioprotective effects of low dose GLP-1 in generally healthy individuals A Review on the Efficacy and Safety of Oral Semaglutide PMC What the evidence suggests: Low-dose Semaglutide may reduce the rate of major cardiovascular events and death in patients with metabolic disease
Some researchers experience injection site reactions including redness, swelling, or itching, which are typically mild and resolve on their own
Sales of GLP-1 therapies have grown by 58% in 2023 compared with 2022, with the diabetes drugs Novo Nordisks Ozempic (semaglutide) and Lillys Mounjaro (tirzepatide) driving most of the volume growth, according to IQVIA data
That leaves 9mg potentially beyond its safe use date
As demonstrated in a 2019 randomized, controlled trial, administration of Akkermansia muciniphila led to decreased body weight and fat mass compared with placebo, while also reducing insulin sensitivity, insulinemia, and plasma total cholesterol.15 Clostridium butyricum WB-STR-0006 The gut health benefits of Clostridium butyricum are succinctly laid out in a 2022 review, which describes the species as widely effective against three common GI pathogens: Clostridioides difficile, Helicobacter pylori , and Escherichia coli .16 In the United States alone, these pathogens cause hundreds of thousands of infections every year, plus tens of thousands of deaths.17 18 19 It seems to have anti-obesity effects , too, as rodent studies have shown that it increases levels of gut acids that can suppress appetite and inhibit fat storage.20 Also (to highlight this species name), Clostridium butyricum produces butyrate, a short-chain fatty acid whose levels inversely correlate with risk for inflammatory bowel diseases and positively correlate with improved diabetic biomarkers .21 22 Anaerobutyricum hallii WB-STR-0008 The presence of Anaerobutyricum hallii gives us a second butyrate producer in the Pendulum formula.23 Its moreover a key contributor to the formation of a different short-chain fatty acid called propionate, which is believed to inhibit fat storage and reduce serum cholesterol levels .24 Clostridium beijerinckii WB-STR-0005 Clostridium beijerinckii is another known butyrate producer.25 It furthermore plays a regulatory role in the gut microbiome, keeping harmful bacteria in check while promoting the proliferation of beneficial species
