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Compounded tirzepatide became widely used during shortages of brand-name medications like Mounjaro and Zepbound in 20222023

After initiation of WEGOVY, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back), and which may or may not be accompanied by nausea or vomiting

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When given a high dose weekly, people without diabetes can lose about 15 percent of their body weight, on average, after nearly 16 months

Diabetes Care 34 , S258S263 (2011)