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In macrophages, activation of pro-inflammatory pathways induces expression of aconitate decarboxylase 1 or (ACOD1), which produces itaconate from the Krebs cycle intermediated cis -aconitate

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The science behind NAD+ Scientists at Harvard Medical School led by Dr David Sinclair, professor of genetics, have found in mice that NAD+ could revive cells in older mice to resemble tissue in much younger mice

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