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Electron microscopy revealed that this particle exclusively appeared in melanoma cells
Additionally, there are drug efflux pumps such as p -glycoprotein (P-gp), multidrug resistance associated protein (MRP) and drug metabolic enzymes, at the BBB to remove and/or inactivate small drug molecules from the brain [1]
For researchers who need protocol-specific dose control, separate vials are better
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ApoE does so many different things that trying to target it in various traditional wayslike small-molecule approaches to interfere with one of its actions, for examplehasn't really worked, says Howard Fillit, cofounder and chief science officer at ADDF
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