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TMZ treatment results in the upregulation of CHAC1, which subsequently interacts with and inhibits the Notch3 protein

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In addition to its benefits in diabetes and cancer, metformin has been shown to promote weight loss and protect against cardiovascular disease, Alzheimer disease, and non-alcoholic fatty liver disease (Forouzandeh 2014

The active ingredient is the same molecule, but manufacturing standards, quality assurance processes, and batch testing protocols differ