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They all had failed existing therapy for neuropathy, including the use of antiinflammatory agents (nonsteroidal antiinflammatory drug [NSAIDs], glucocorticoids and methotrexate principally), as well as antiepileptics and antidepressants

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The lack of monitoring means we cannot determine from existing clinical trial data whether semaglutide causes clinically significant b12 deficiency in typical patients

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