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Thermal Stress: Elevated temperatures accelerate both hydrolysis and oxidation, often revealing aggregation tendencies and cyclic degradation products

In clinical trials, severe gastrointestinal adverse reactions were reported more frequently among patients receiving Saxenda (4.8%) than placebo (1.4%)

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( f ) Food intake, ( g ) RER (effect of treatment F(1,10) = 6.34 p = 0.031), ( h ) energy expenditure (with ANCOVA using BW as covariate), ( i ) ambulatory activity and ( j ) body weight change of WT mice treated with VEH or acyl-GIP ( d - j , n = 6 per group