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5 mg vial = 5,000 mcg total 2 mL water = 2,500 mcg per mL 2,500 mcg target = 1.0 mL draw TB-500 10 mg vial with 3 mL example A 10 mg TB-500 vial mixed with 3 mL gives about 3,333 mcg/mL, or 3.33 mg/mL

Impairment in CFTR functionality is associated to loss of tissue homeostasis that leads to the accumulation of viscous mucus creating the ideal environment for bacterial infections and inflammation

Long-term safety data in extended rodent studies (90+ days) would be essential before translating this to human protocols

However, the metabolic activation and protein adduct formation, also in mitochondria, are only marginally lower in rats compared to mice but there was no relevant mitochondrial dysfunction and oxidant stress in rats [124]

Because it stimulates powerful growth pathways in the brain, researchers have flagged several risks and the absence of human trials means its long-term effects are unknown