depletion of glutathione Summary. (GSH) and increased ROS production glutathione levels decline with toxin

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A number of GPCRs (McCulloch et al., 2001), including the CB1 cannabinoid receptor (Koch et al., 2006), and MOR and DOR (Koch et al., 2003, 2004, 2006), activate PLD to affect exocytosis, cytoskeletal reorganization, and cellular proliferation (Ghosh et al., 2003

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