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J., Lockard, M

Half-life after subcutaneous injection in humans has been characterized as short, in the range of roughly 2 hours based on peptide pharmacokinetic conventions, which is why protocols use multiple daily injections

Exposure to mesh induces inflammatory reactions because asymptomatic mesh infection prevents the mesh from integrating with its surroundings (Mangir et al

The four primary mechanisms involved include enzymatic degradation, target modification, prevention of drug entry, and efflux pump activation 19,45