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Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B

Multiple preclinical and clinical studies showed that epigenetic mechanisms are involved in the pathophysiology and treatment of stress-related depressive and cognitive disorders

The trial included 60 adult participants (mean age approximately 49) who had clinical follow-up with labs every 2 months for up to 2 years, with some withdrawing early due to spontaneous remission, indication for definitive therapy (e.g., thyroidectomy or radioiodine), or an intolerance to the treatment

PMID: 16352683

That means understanding how your GH axis markers interact with your insulin sensitivity, your thyroid function, your sex hormone status, and your cardiovascular risk profile and arriving at a recommendation that accounts for all of it