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Discussion Our concept, which we verified in several previous paper [24, 32, 33, 42], is that if we mimic the specific expression pattern of nutrient transporters at the BBB with a combination of two or three different ligands a more specific targeting of nanoparticles across the BBB can be achieved

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One major mechanism involves activation of the PI3K/Akt signaling pathway, which enhances cell survival and reduces reactive oxygen species (ROS) generation [35, 97]

The results are cumulative, and each cycle builds on the previous one, which is why we structure protocols across multiple cycles rather than expecting full transformation in 30 days

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