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The active ingredient may not be what you think it is Some compounded GLP-1 products use what's called a salt form of the active ingredient, like "semaglutide sodium" or "semaglutide acetate." These are not the same chemical entity as the FDA-approved semaglutide base used in Ozempic and Wegovy

Common Adverse Effects The most frequently reported complications include: Abdominal pain and cramping: Often severe and requiring medical attention Rectal burning and irritation: The coffee solution can damage delicate rectal and colonic tissue Bloody stools: Indicating intestinal injury or inflammation Proctocolitis: Inflammation of the rectum and colon lining that can become chronic Electrolyte imbalances: Particularly dangerous depletion of sodium and potassium Dehydration: From excessive fluid loss and electrolyte disturbances Life-Threatening Complications Most alarming are the documented fatalities associated with coffee enemas

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Variability in anticoagulation management of patients on extracorporeal membrane oxygenation: an international survey

Sergey Terushkin, MD, FACS, is a board-certified surgeon and weight loss specialist at Florida Surgery & Weight Loss Center in Hollywood, FL