Prostaglandins interact directly with local pain receptors
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[DOI] [PubMed] [Google Scholar] 40.Mller P, Singh A, Orci L, et al

Common, expected side effects (still worth discussing if persistent): Mild to moderate nausea Early satiety (getting full very quickly) Bloating or gassiness Constipation or looser stools "Sulfur burps" (a rotten-egg burp that can happen when stomach contents sit longer) Red flags that should prompt urgent medical attention (not "wait it out"): Severe or persistent vomiting, inability to keep fluids down, or signs of dehydration Severe abdominal pain (especially right upper quadrant pain), fever, or jaundice, which can suggest gallbladder or pancreatic issues Symptoms that feel like profound food-stasis: ongoing nausea/fullness, vomiting undigested food, or worsening reflux that doesn't respond to basic measures, this can raise concern for significant delayed gastric emptying (gastroparesis) Black/tarry stools, blood in vomit or stool, fainting, chest pain, or shortness of breath If you're on a GLP-1 and your symptoms feel "too intense to function," that's information, not weakness

Patients (or caregivers) use them to self-administer insulin at home or in clinics, usually injecting into fatty areas like the abdomen, thigh, buttock or upper arm