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Corroborating these findings, in a previous fMRI study conducted on healthy adult males, with the intake of l-theanine and l-theaninecaffeine combination, we observed decreased reactivity of the posterior DMN while responding to Go stimuli as well as avoiding NoGo stimuli 33

These synthetic GR agonists, which are resistant to 11-HSD inactivation, are widely used in pediatric and adult patients as anti-inflammatory agents, as well as in preterm fetuses/newborns to prevent prematurity-related morbidity and mortality

Of the 36 that met inclusion criteria, 35 were preclinical animal studies

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