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Semaglutide is part of a class of drugs called glucagon-like peptide-1 (GLP-1) agonists

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At the same time, all studies that specifically addressed changes at nearby synapses found that input-specificity breaks down at short distances (Schuman and Madison, 2014, The hippocampus represents a classical experimental system to study synaptic plasticity, and it has been a structure of choice for most studies of plasticity of excitatory synaptic transmission to inhibitory interneurons (Figure 1 and Table 1)

The half-life of semaglutide allows some activity to persist for about 10 days, but by day 14 (two weeks), receptor engagement drops to clinically insignificant levels