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A 2024 npj Aging paper (doi:10.1038/s41514-024-00160-6) demonstrated that adiponectin receptor expression on B cells declines with age, reducing endogenous PEPITEM levels and allowing progressive T-cell infiltration of metabolically active tissues a direct molecular mechanism for inflammaging

Semaglutide works by activating GLP-1 receptors in the brain to reduce hunger and slow gastric emptying, leading to sustained weight loss over time

Improved Repair and Recovery: Tesamorelin helps reduce inflammation, creating a more favourable environment for healing and repair, while also stimulating GH to support cellular regeneration

What to Do: Supplementation Protocols by Deficiency Stage The right intervention depends on why youre deficient and how severe it is