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Systemic Inflammation Level of Evidence: Limited evidence While ALCs effects on neuroinflammation are well-documented, evidence for systemic anti-inflammatory effects is more limited

In the brain of patients with mild cognitive impairment (MCI) and those with AD, the level of markers of oxidative damage to DNA, proteins, and lipids is increased, while the expression and activities of glutathione and antioxidant enzymes are reduced (reviewed in 102)

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Side-effect trends mirror this split MT-1 reactions stay skin-focused, whereas MT-2 extends into systemic responses