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Sprague and coworkers also demonstrated depressed ATP export from diabetic human RBCs, in parallel with reduced abundance in the RBCs of the G-protein (G i ) implicated in transducing regulated ATP export (Sprague et al., 2006)

Onglyza can be administered in combination with existing oral hypoglycemic agents, such as sulfonylurea drugs, thiazolidines, biguanides, short-acting insulin secretagogues, and alpha-glucosidase inhibitors