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There are no controlled trials of clebopride (D2 antagonist) in gastroparesis other than in dyspepsia with radiologically delayed gastric emptying, a criterion not currently accepted for gastroparesis ( 1 and 5-HT 4 agonist and 5-HT 2 antagonist) was superior to placebo in a parallel design study of 19 patients with dyspepsia associated with postprandial distress and mildly to moderately delayed gastric emptying (Portincasa et al., 2009)

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Activation of these receptors triggers two complementary processes: it accelerates lipolysis (the breakdown of stored triglycerides into free fatty acids for energy) while simultaneously inhibiting lipogenesis (the conversion of glucose and other substrates into new fat stores)