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By the end of the study, the GHK-Cutreated mice performed nearly at the level of wild-type controls, suggesting substantial restoration of working memory and executive function

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Blood urea nitrogen (BUN) and serum creatinine (Scr) levels, and urinary calcium and oxalate levels increased were increased remarkably in this model (Fig

In detail, elevation of HDAC6 promotes the formation of aggresome, which emerges as a cytoprotective response in the clearance of toxic misfolded protein aggregates found in neurodegenerative disease such as Parkinsons disease [90], via binding polyubiquitinated misfolded protein including CFTR-F508 [91]

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