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Ipamorelin is a synthetic peptide that stimulates the release of growth hormone (GH) from the pituitary gland
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The magnitude of this effect varies with GH pulse amplitude and duration again favoring robust pulsatile protocols (CJC-1295/ipamorelin) over gentle stimulation (sermorelin alone)
The primary mechanism is therefore identical to Sermorelin (GHRH 1-29) and CJC-1295 (tetra-substituted analog), but pharmacokinetics differ: approximately 8-minute plasma half-life for Tesamorelin via SC route (FDA Egrifta SV label) versus 10-15 min for Sermorelin and 6-8 days for CJC-1295 DAC
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