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Within these pathways, the genes COL2A1 , ITGB4 , and CHAD were particularly noteworthy

Although much is known about the mechanisms and functional consequences of metabolic alterations in CRC, how these processes interact with diet, obesity and lifestyle remains unclear

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SCFAs (acetate, propionate, butyrate), produced through the fermentation of dietary fiber, contribute to the maintenance of intestinal barrier integrity, modulation of systemic immune responses, and can cross the BBB to influence microglial maturation and neuronal function ( Secondary bile acids, generated via microbial deconjugation and dehydroxylation, act on nuclear receptors such as FXR and the G protein-coupled receptor TGR5, thereby participating in the regulation of hepatic metabolism and inflammatory signaling within the CNS

If side effects persist despite management strategies, discussing alternative compounds with your prescriber becomes essential