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PIONEER 6 was conducted on 3183 patients and followed up for 69 weeks to assess the cardiovascular outcomes of once daily oral semaglutide in an event-driven, randomized, double-blind, placebo-controlled trial involving patients at high cardiovascular risk (aged 50 years with established cardiovascular or chronic kidney disease or aged 60 years with cardiovascular risk factors only) and revealed that oral semaglutide was safe in patients with T2D [11]

The Effect of Glucagon-Like Peptide-1 Receptor Agonists Liraglutide and Semaglutide on Cardiovascular and Renal Outcomes Across Baseline Blood Pressure Categories: Analysis of the LEADER and SUSTAIN 6 Trials