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A detailed retelling of GLP-1 development, which served as the basis of this article, can be found in an article published in Perspectives in Biology and Medicine by Jeffrey Flier, who was involved in the early GLP-1 work

Glutathione stability is the limiting factor in pre-mixed combination formulations

Still, Apovian says that the potential suggested by the retatrutide results is "really fantastic," although she adds that having a variety of weight loss medications is important