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The modified amino acid, 4-hydroxyproline, is metabolized to glyoxylate and pyruvate via the action of 4-hydroxy-2-oxoglutarate aldolase 1 (encoded by the HOGA1 gene)

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Lab Invest 92 , 224235 (2012)

Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions

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