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Kaufman emphasized that the results are not uniform as always, its a subset that responds

Jay Kenney, nutrition research specialist and educator at the Pritikin Longevity Center 1 Nature Medicine, published online 7 April 2013

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Residues Y239 (TM5), Y358 (TM7) and F443 (TM10) all positioned ideally to form strong cation-$\pi$ interactions, with nearby residues Y211, F359, Y387 and Y447 positioned within reasonable distance to form weak cation-$\pi$ interactions