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There is no clinical penalty for slower escalation

At the class level, both have a GI-dominant profile (nausea, vomiting, diarrhoea) that concentrates at dose escalation

For further information: DOI:10.1001/jamainternmed.2022.0338 Keywords: GLP-1 RA, Glucagon-like peptide-1 receptor agonists, biliary disease, Gallbladder disease, higher doses, Longer duration of GLP-1 RA, cholelithiasis, cholecystitis, GRADE framework, biliary cancer, JAMA Internal Medicine

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