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and served on advisory boards for Boehringer Ingelheim, Eli Lilly, Nestl Health Science, Novo Nordisk, and Pronokal

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Additional hallmarks include reduced mitogenic activity, overproduction of reactive oxygen species (ROS), reduced concentrations over time of growth factors, and decreased levels of tissue inhibitors of metalloproteinases (TIMPs) compared to acute wounds, and impaired angiogenesis