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In a transcriptomic analysis of pre-menopausal and peri-menopausal stromal fibroblasts, over 1,000 genes were found to be differentially expressed between these two age groups (Erikson et al., 2017)

The average body mass index when they enrolled in the study was 37 kg/m 2 , which is considered obesity

This review critically evaluates the current standard of care (SOC) and synthesizes the preclinical insights and clinical trial data, examining both successes and failures to highlight challenges in drug development