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We discuss how copper also plays a key role in proteostasis and interacts either directly or indirectly with many of the key aggregate-prone proteins implicated in ALS, such as TDP-43, C9ORF72, SOD1 and FUS as well as the effect of their aggregation on copper homeostasis

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It requires a holistic approach that includes diet modifications, physical activity, and behavioral changes combined with careful selection and dosing of weight loss medication, including but certainly not limited to the option of GLP-1s