glp 1 r for weight loss Science's 2023 Breakthrough: GLP-1R Agonists GLP-1 Drug Savings: A Complete

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Gradual retatrutide escalation

GLP-1s are not recommended during pregnancy, but newer studies show they dont seem to increase the chance of developmental issues (2,7,13)

The common link is that GLP-1s activate receptors that then work on driving down metabolic risk factors through the following mechanisms: Enhancing glucose dependent insulin secretion Slowing gastric emptying and decreasing appetite Reducing postprandial glucagon and food intake UpToDate 2 : (1) ingestion of food results in (2) release of gastrointestinal peptides (GLP-1 and GIP: glucose-dependent insulinotropic polypeptide, gastric inhibitory peptide) and (3) pancreatic beta cell hormones (insulin and amylin)

The mechanism is mainly through stimulation of the nitric oxide system, with secondary effects on VEGFR-2 (which drives angiogenesis and explains the wound healing), the serotonin and dopamine systems, COX-2, and HO-1