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As observed previously 13 , the putative flavan-3,3,4-triol ( 4 ) was not stable during purification, and confirmatory time-course experiments showed almost complete degradation of the intermediate ( 4 ) within 24 h (Extended Data Fig

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Study secondary end points included the comparison of ACE1 and ACE2 receptor levels between the supplement and placebo groups of Cohort 2 (analyzed at baseline and every 7 days for 21 days) and the ACE1/ACE2 ratios in both supplement and placebo groups of each cohort