Use of GLP-1 receptor agonist (GLP-1RA) within 3 months of study screening
Diabetes 45:10241029 Heitzer T, Finckh B, Albers S, Krohn K, Kohlschutter A, Meinertz T (2001) Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress
In a review by Fintini et al., six patients with PWS and concomitant diabetes were treated with GLP-1 RAs, liraglutide (1.2 1.8 mg daily) in four patients and exenatide (20 mcg daily) in two patients, showing only a tendency for BMI and waist circumference reduction after 24 months of treatment (36)
This delivery method protects the nutrient from stomach acid and uses a phospholipid shell to support absorption directly into the bloodstream and cells
Giving your body time to adapt at each dose level significantly reduces gastrointestinal side effects