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Finally, although our meta-analysis showed that GLP-1 receptor agonists increased the risk of overall thyroid disorder, due to the decrease in sample size, it did not show statistically significant results for specific thyroid disorder

Additionally, "some herbal or 'natural' remedies for constipation, like aloe, cascara, or senna-based products are stimulant-based," says Hamilton, "meaning they work by causing the intestines to contract more forcefully." While these supplements can be effective for short-term relief, Hamilton warns that frequent use can lead to cramping, diarrhea, or dependence

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