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The Fenton Reaction: Free iron can be involved in the formation of free radicals by the superoxide-driven Fenton reaction, leading to glutathione depletion, oxidative stress, degradation of protein and nucleic acids, and lipid peroxidation

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Studies on the progression of renal tubular epithelial mesenchymal transition (EMT) in diabetic nephropathy found that XBP1 overexpression increased HRD1 expression and inhibited NRF2 expression, enhancing cellular susceptibility to ferroptosis