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After a washout period of at least 3 weeks, patients received the complementary intervention

introduced Zr into a manganese porphyrin-based MOF (Mn-MOF) to construct a biocompatible nanosensitizer along with the capacity of GSH exhaustion-enhanced ferroptosis (Figure 5F) (Figure 5G), thus elevating Mn-MOF-induced ROS concentration, leading to the deactivation of GPX4 and ROS-enhanced ferroptosis

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Central insulin resistance contributes to neurodegeneration by promoting mitochondrial failure, protein aggregation, and apoptosis

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