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In addition, GLP-1 receptor agonists slow gastric emptying, which has led to evolving recommendations about when to discontinue these medications before anesthesia

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A meta-analysis showed that the increase in bone fracture risk was primarily driven by results from the CANVAS trial that included older patients with increased risk of CVD and a low baseline eGFR, and suggested that it may be related to indirect effects such as falls resulting from AEs related to volume depletion [72]