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In summary, MSC- and exosome-based therapies mitigate OA ferroptosis through the METTL3ACSL4, SNHG7miR-485-5pFSP1, and GOT1CCR2Nrf2 axes

Au HCT, Zheng YJ, Le GH, Wong S, Teopiz KM, Kwan ATH, et al

Metabolic enzymes of amino acid balance the catabolism and biological transformation of amino acids in cells through dynamic regulation of metabolites, and multiple metabolic enzymes of amino acids therapies have demonstrated efficacy in cancer treatment [110] (Table 1)