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Differential effects were identified by contrasting the coefficients from the combination drug treatment to the addition of each drug treatment in isolation

Mechanism of Action 5-Amino-1MQ exerts its metabolic effects primarily through competitive inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme belonging to the methyltransferase superfamily that is expressed in multiple tissues including liver, adipose tissue, skeletal muscle, kidney, and brain, with particularly high expression in visceral (abdominal) adipose tissue - the fat depot most strongly associated with metabolic disease

Neurological changes, such as numbness and tingling in the hands and feet, can also occur