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Combination therapy has several potential advantages, including (1) increased durability of the glycaemic effect [225,226,227], addressing therapeutic inertia, (2) simultaneous targeting of the multiple pathophysiological processes characterised by type 2 diabetes, (3) impacts on medication burden, medication-taking behaviour and treatment persistence and (4) complementary clinical benefits (e.g
this effect being particularly evident with Mmp2 and Mmp9 expression
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Hence, prevention and management of T2DM and its associated complications in this population are of paramount importance
5.4% after 12 hr, n=205
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