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H., Ross, J

Kaye GL, Kruszynska YT, Harry DS, Heslop K, Johnston DG, McIntyre N

Skin conditions like eczema need extra moisture because the outer layer is not working as it should

Ubiquitin, a conserved 76-amino acid protein, is first activated in an ATP-dependent manner by E1 ubiquitin-activating enzymes, then transferred to E2 conjugating enzymes, and finally attached to target proteins by E3 ubiquitin ligases, which provide the critical element of substrate specificity (Fig