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Neuronal injury, gliosis, and glial proliferation in two models of temporal lobe epilepsy

Figure 5 Downstream cellular mediators of Dihexa protection Activation of the receptor tyrosine kinase c-Met leads to the recruitment of many signaling mediators and ultimately the activation of downstream signals, most notably Akt-TOR and Ras-ERK (Organ and Tsao, 6A)

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In vivo rodent models have explored tissue-specific IGF-1R engagement by comparing the biodistribution and signalling footprint of IGF-1 LR3 against the native 70-amino acid ligand