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Sikiric and colleagues have proposed nitric oxide system involvement, while other groups have documented effects on VEGF receptor 2 expression, growth-hormone receptor upregulation, and dopamine pathway modulation

In parallel, advances in peptide chemistry and structural biology have enabled the design of aggregation inhibitors, receptor-selective neuropeptide analogues, and cell-penetrating or brain-targeted peptide conjugates that modulate key pathways, including proteostasis, insulin and incretin signaling, neurotrophic support, and microglial activation

33 ChangA.StaugaitisS

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