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Most patients may experience gastrointestinal disturbances such as nausea, vomiting, diarrhea, and constipation

FUTURE LANDSCAPE OF OBESITY PHARMACOTHERAPY In addition to the published STEP trials, the programme includes three further ongoing global phase IIIa studies in adolescents with obesity (STEP TEENS), 69 in individuals with heart failure and obesity (STEPHFpEF) 70 and in individuals with heart failure and obesity with type 2 diabetes (STEPHFpEFDM) 71 (Figure 2)

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In the obesity group, there was a significant and clinically meaningful reduction in body weight of 4.74% at week 8, with weight continuously decreasing during the 8-week treatment period

Discovery is ongoing