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NNMT inhibition in cell culture models has been associated with enhanced myogenic commitment, suggesting that the same NAD+/SAM preservation mechanism that restores adipocyte energy expenditure may also support muscle regeneration processes

The evidence that is currently available is not sufficient enough to suggest that a lack of vitamin B12 has any significant or specific impact on weight, regardless of whether it causes weight gain or loss

No obvious weight loss yet- but again its only been 3 weeks so I am sure this will change over time

Studies have found that high NNMT expression promotes the release of inflammatory factors in adipose tissue, and NNMTi can effectively alleviate adipose inflammation and improve the microenvironment by inhibiting NNMT

Progress on skin is gradual